目的 研究内蒙古蒙古黄芪的化学成分。方法 采用D101大孔树脂柱色谱法和半制备高效液相色谱法进行分离, 运用各种波谱法鉴定分离所得化合物的结构式。结果 分离鉴定了7个化合物: 4, 4′-二甲基-6′-羟基查尔酮(1), 4-甲氧-4′, 6′-二羟基查尔酮(2), 7, 4′-二羟基二氢黄酮(3), 4, 4′, 6′-三羟基查尔酮(4), 4′-羟基二氢黄酮-7-O-β-D-葡萄糖苷(5), 2′-羟基-3′, 4′-二甲氧基异黄烷-7-O-β-D-葡萄糖苷(6), 3, 2′-二羟基-3′, 4′-二甲氧基异黄烷-7-O-β-D-葡萄糖苷(7)。结论 所有化合物均为首次该植物中分得。
Abstract
OBJECTIVE To study the chemical constituents of roots of Astragalus membranaceus (Fisch) Bge. var. mongholicus (Bge) Hsiao. METHODS The chemical constituents of Astragalus membranaceus(Fisch) Bge. var. mongholicus (Bge) Hsiao were isolated and purified by D101 column chromatography and preparation HPLC. Their structures were identified by physicochemical properties and spectral analysis methods. RESULTS Seven compounds were obtained and identified as 4, 4′-dimethyl-6′-hydroxychalcone(1), 4-methoxy-4′, 6′-dihydroxychalcone(2), 7, 4′-dihydroxyflavonone(3), 4, 4′, 6′-trihydroxychalcone(4), 4′-hydroxyflavonone-7-O-β-D-glucoside(5), 2′-hydroxy-3′, 4′-dimethylisoflavan-7-O-β-D-glucoside(6), and 3, 2′-dihydroxy-3′, 4′-dimethylisoflavan-7-O-β-D-glucoside(7). CONCLUSION All these compounds were isolated from this plant for the first time.
关键词
蒙古黄芪 /
4 /
4′-二甲基-6′-羟基查尔酮 /
4-甲氧-4′ /
6′-二羟基查尔酮 /
7 /
4′-二羟基二氢黄酮 /
高效液相色谱法
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Key words
Astragalus membranaceus(Fisch) Bge. var. mongholicus (Bge) Hsiao /
4, 4′-dimethyl-6′-hydroxychalcone /
4-methoxy-4′, 6′-dihydroxy chalcone /
7, 4′-dihydroxyflavonone /
HPLC
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中图分类号：
R284
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参考文献
[1] Ch. P(2010) Vol Ⅰ(中国药典2010年版.一部). 2010:283-284.[2] Standard of Traditional Mongolian Medicinal Materials (内蒙古蒙药材标准).Chifeng:Inner Mongolia Science and Technology Press, 1987:245-246. [3] ZHAO M, DUAN J A, HUANG W Z, et al. Isoflavans and isoflavone from Astragalus hoantchy . J Chin Pharm Univ(中国药科大学学报), 2002, 33(4):274-276.[4] BIAN Y Y, GUAN J, BI Z M, et al. Studies on chemical constituents of Astragalus membranaceus (Fisch.) Bge. var. mongholicus(Bge.) Hsiao. Chin Pharm J (中国药学杂志), 2006, 41(16):1217-1221.[5] LUO Z, SU M Z, YAN M, et al. Chemical constituents of Astragalus membranaceus var. mongholicus. Chin Trad Herb Drug (中草药), 2012, 43(3):458-462.[6] SUN J, ZHANG L, ZHANG X L, et al. Chemical constituents from Astragalus membranaceus var. mongholicus . Drugs & Clinic(现代药物与临床), 2013, 28(2):138-143.[7] BI Z M, YU Q T, LI P, et al. Flavonoids from the aerial parts of Astragalus mongholicus . Chin J Nat Med(中国天然药物), 2007, 15(14):263-265.[8] LI R F, ZHOU Y Z, QIAO L, et al. Chemical constituents of Astragalus membranaceus Bge. var. mongholicus(Bge.) Hsiao. J Shenyang Pharm Univ(沈阳药科大学学报), 2007, 24(1):20-22.[9] WEN Y H, CHENG L, ZHENG D, et al. Chemical constituents of Astragalus membranaceus var. mongholicus . Prac Pharm And Clin Rem (实用药物与临床), 2010, 13(2):115-118. WANG J L, YU H M, LI W H, et al. Studies on chem ical constituents of Astragalus dahuricus . Chin J Chin Mat Med (中国中药杂志), 2008, 33(4):414-416. ZHANG L T, SUN J L, GU X B, et al. Separation, purif ication and structural identif ication of secondary metabolites of actinomycete SPRI0518. Chem Bioeng(化学与生物工程), 2006, 23(9):29-31. LIANG H, ZHANG R Y. Studies on the chemical constituents of Yuanguogancao extract. J Beijing Med Univ(北京医科大学学报), 1992, 24(5):399-400. LIU W, CHEN J, ZUO W J, et al. A new isoflavane from processed Astragalus membranaceus . Chin Chem Lett(中国化学快报), 2007, 18:1092-1094.
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脚注
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基金
十二五国家科技支撑计划项目(2011BAO7B01)
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